An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

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Arumugam, Natarajan and Almansour, Abdulrahman and Kumar, Raju and Menéndez Ramos, José Carlos and Sultan, Mujeeb and Karama, Usama and Ghabbour, Hazem and Fun, Hoong-Kun (2015) An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction. Molecules, 20 (9). pp. 16142-16153. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules200916142




Abstract

A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10-benzylideneanthracen9(10H)-one as a dipolarophile in 1-butyl-3-methylimidazolium bromide([bmim]Br), an ionic liquid. This reaction proceeded regio- and diastereoselectively, in good to excellent yields.


Item Type:Article
Uncontrolled Keywords:multicomponent reactions; 1,3-dipolar cycloaddition reactions; spirooxindoles; spiropyrrolidines; ionic liquids
Subjects:Medical sciences > Pharmacy > Organic chemistry
ID Code:69035
Deposited On:03 Feb 2022 12:50
Last Modified:03 Feb 2022 13:43

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