The role of the Microbiota-Gut-Brain Axis in the health and illness Condition: a focus on Alzheimer’s Disease

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Fuente del Rey, Mónica de la (2021) The role of the Microbiota-Gut-Brain Axis in the health and illness Condition: a focus on Alzheimer’s Disease. Journal of Alzheimer's Disease, 81 (4). pp. 1345-1360. ISSN 1387-2877

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Official URL: https://doi.org/10.3233/JAD-201587




Abstract

Trillions of commensal microbes live in our body, the majority in the gut. This gut microbiota is in constant interaction with the homeostatic systems, the nervous, immune and endocrine systems, being fundamental for their appropriate development and function as well as for the neuroimmunoendocrine communication. The health state of an individual is understood in the frame of this communication, in which the microbiota-gut-brain axis is a relevant example. This bidirectional axis is constituted in early age and is affected by many environmental and lifestyle factors such as diet and stress, among others, being involved in the adequate maintenance of homeostasis and consequently in the health of each subject and in his/her rate of aging. For this, an alteration of gut microbiota, as occurs in a dysbiosis, and the associated gut barrier deterioration and the inflammatory state, affecting the function of immune, endocrine and nervous systems, in gut and in all the locations, is in the base of a great number of pathologies as those that involve alterations in the brain functions. There is an age-related deterioration of microbiota and the homeostatic systems due to oxi-inflamm-aging, and thus the risk of aging associated pathologies such as the neurodegenerative illness. Currently, this microbiota-gut-brain axis has been considered to have a relevant role in the pathogenesis of Alzheimer’s disease and represents an important target in the prevention and slowdown of the development of this pathology. In this context, the use of probiotics seems to be a promising help.


Item Type:Article
Uncontrolled Keywords:Aging; Alzheimer’s disease; Endocrine system; Immune system; Microbiota; Microbiota-gut-brain axis; Nervous system; Neuroimmunoendocrine communication
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Neurosciences
ID Code:69170
Deposited On:13 Dec 2021 16:08
Last Modified:14 Dec 2021 08:25

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