Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

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Sánchez Gómez-Serranillos, Marta and González Burgos, Elena and Iglesias Peinado, Irene and Gómez-Serranillos Cuadrado, María Pilar (2020) Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules, 25 (6). p. 1324. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules25061324




Abstract

Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014–2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera, but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes.


Item Type:Article
Uncontrolled Keywords:Aloe vera; pharmacology; extracts; isolated compounds
Subjects:Medical sciences > Pharmacy > Pharmacology
ID Code:69261
Deposited On:21 Dec 2021 16:08
Last Modified:22 Dec 2021 08:17

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