Mechanochemical Synthesis of Primary Amides

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Gómez-Carpintero Jiménez, Jorge and Sánchez Cebrián, J. Domingo and González Matilla, Juan Francisco and Menéndez Ramos, José Carlos (2021) Mechanochemical Synthesis of Primary Amides. The Journal of Organic Chemistry, 86 (20). pp. 14232-14237. ISSN 0022-3263

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Official URL: https://doi.org/10.1021/acs.joc.1c02350




Abstract

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.


Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2021)

Subjects:Sciences > Chemistry > Chemistry, Organic
ID Code:69344
Deposited On:21 Dec 2021 11:29
Last Modified:18 Feb 2022 09:29

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