Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

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Tendilla Beltrán, Hiram and Coatl Cuaya, Heriberto and Meneses Prado, Silvia and Vázquez Roque, Ruben Antonio and Brambila, Eduardo and Tapia Rodríguez, Miguel and Martín Hernández, David and Garcés Ramírez, Linda and Muñoz Madrigal, José Luis and Leza Cerro, Juan Carlos and Flores, Gonzalo (2021) Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats. Schizophrenia Research, 235 . pp. 17-28. ISSN 0920-9964, ESSN: 1573-2509

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Official URL: https://doi.org/10.1016/j.schres.2021.07.014



Abstract

Increased dopaminergic activity in the striatum underlies the neurobiology of psychotic symptoms in schizophrenia (SZ). Beyond the impaired connectivity among the limbic system, the excess of dopamine could lead to inflammation and oxidative/nitrosative stress. It has been suggested that atypical antipsychotic drugs attenuate psychosis not only due to their modulatory activity on the dopaminergic/serotonergic neurotransmission but also due to their anti-inflammatory/antioxidant effects. In such a manner, we assessed the effects of the atypical antipsychotic risperidone (RISP) on the structural neuroplasticity and biochemistry of the striatum in adult rats with neonatal ventral hippocampus lesion (NVHL), which is a developmental SZ-related model. RISP administration (0.25 mg/kg, i.p.) ameliorated the neuronal atrophy and the impairments in the morphology of the dendritic spines in the spiny projection neurons (SPNs) of the ventral striatum (nucleus accumbens: NAcc) in the NVHL rats. Also, RISP treatment normalized the pro-inflammatory pathways and induced the antioxidant activity of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in this model. Our results point to the neurotrophic, antiinflammatory, and antioxidant effects of RISP, together with its canonical antipsychotic mechanism, to enhance striatum function in animals with NVHL.


Item Type:Article
Uncontrolled Keywords:Atypical antipsychotics; Spiny projection neurons; Stereology; MAP kinases; Nrf2; Smad
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Neurosciences
ID Code:69361
Deposited On:22 Dec 2021 09:14
Last Modified:22 Dec 2021 09:17

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