¡Nos trasladamos! E-Prints cerrará el 7 de junio.

En las próximas semanas vamos a migrar nuestro repositorio a una nueva plataforma con muchas funcionalidades nuevas. En esta migración las fechas clave del proceso son las siguientes:

Es muy importante que cualquier depósito se realice en E-Prints Complutense antes del 7 de junio. En caso de urgencia para realizar un depósito, se puede comunicar a docta@ucm.es.

Upconverting Nanoparticles in Aqueous Media: Not a Dead-End Road. Avoiding Degradation by Using Hydrophobic Polymer Shells



Downloads per month over past year

Méndez González, Diego and Torres Vera, Vivian Andrea and Zabala Gutiérrez, Irene and Gerke, Christoph and Cascales Sedano, Concepción and Rubio Retama, Jorge and Gómez Calderón, Óscar and Melle Hernández, Sonia and Laurenti, Marco (2021) Upconverting Nanoparticles in Aqueous Media: Not a Dead-End Road. Avoiding Degradation by Using Hydrophobic Polymer Shells. Small, 18 (8). p. 2105652. ISSN 1613-6810

[thumbnail of Small - 2021 - Mendez‐Gonzalez - Upconverting Nanoparticles in Aqueous Media  Not a Dead‐End Road  Avoiding Degradation by.pdf] PDF
Restringido a Repository staff only


Official URL: https://doi.org/10.1002/smll.202105652


The stunning optical properties of upconverting nanoparticles (UCNPs) have inspired promising biomedical technologies. Nevertheless, their transfer to aqueous media is often accompanied by intense luminescence quenching, partial dissolution by water, and even complete degradation by molecules such as phosphates. Currently, these are major issues hampering the translation of UCNPs to the clinic. In this work, a strategy is developed to coat and protect β-NaYF4 UCNPs against these effects, by growing a hydrophobic polymer shell (HPS) through miniemulsion polymerization of styrene (St), or St and methyl methacrylate mixtures. This allows one to obtain single core@shell UCNPs@HPS with a final diameter of ≈60–70 nm. Stability studies reveal that these HPSs serve as a very effective barrier, impeding polar molecules to affect UCNPs optical properties. Even more, it allows UCNPs to withstand aggressive conditions such as high dilutions (5 μg mL−1), high phosphate concentrations (100 mm), and high temperatures (70 °C). The physicochemical characterizations prove the potential of HPSs to overcome the current limitations of UCNPs. This strategy, which can be applied to other nanomaterials with similar limitations, paves the way toward more stable and reliable UCNPs with applications in life sciences.

Item Type:Article
Additional Information:

Received: September 15, 2021 / Revised: November 4, 2021 / Published online: December 13, 2021; Issue Online:
24 February 2022

Uncontrolled Keywords:degradation, dissolution, phosphates, polymers, protection, shells, upconversion nanoparticles
Subjects:Sciences > Physics > Materials
Sciences > Physics > Optics
Sciences > Physics > Particles
ID Code:69398
Deposited On:23 Mar 2022 12:13
Last Modified:23 Mar 2022 15:17

Origin of downloads

Repository Staff Only: item control page