Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

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Maestú Unturbe, Fernando and de Haan, Willem and Busche, Marc Aurel and DeFelipe, Javier (2021) Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology. Ageing Research Reviews, 69 . p. 101372. ISSN 1568-1637

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Official URL: https://doi.org/10.1016/j.arr.2021.101372



Abstract

Our incomplete understanding of the link between Alzheimer’s Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfunction. While there are emerging (non-)pharmacological options to influence this imbalance, the complexity of human brain dynamics has hindered identification of an optimal approach. We suggest that focusing on the integration of neurophysiological aspects of AD at the micro-, meso- and macroscale, with the support of computational network modeling, can unite fundamental and clinical knowledge, provide a general framework, and suggest rational therapeutic targets.


Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Excitation/inhibition imbalance, Functional networks, Amyloid protein, Tau protein, Animal models, Alzheimer’s disease, Microscale, Meso scale, Macro scale, Computational neuroscience, Hyperexcitability, Hypersynchronization
Subjects:Medical sciences > Medicine > Neurosciences
ID Code:69470
Deposited On:10 Jan 2022 14:38
Last Modified:18 Feb 2022 10:56

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