De novo bone formation around implants with a surface based on a monolayer of multi‐phosphonate molecules. An experimental in vivo investigation

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Sanz Esporrin, Javier and Di Raimondo, Riccardo and Vignoletti, Fabio and Núñez, Javier and Muñoz, Fernando and Sanz Alonso, Mariano (2021) De novo bone formation around implants with a surface based on a monolayer of multi‐phosphonate molecules. An experimental in vivo investigation. Clinical Oral Implants Research, 32 (9). pp. 1085-1096. ISSN 0905-7161

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Official URL: https://doi.org/10.1111/clr.13803



Abstract

Objectives: The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multiphosphonate molecules on the de novo bone formation and osseointegration.
Material and Methods: The study was designed as an animal preclinical trial with intra-animal control and two healing periods, 2 and 8 weeks, to compare implants with an identical macro-design but with two different surfaces. Eight female Beagle dogs participated in the study. Control implants had a moderately rough surface combining sandblasting and acid etching; test implants had an additional monophosphonate layer covalently bonded to titanium. Histologic and radiographic (micro-CT) outcome variables were evaluated.
Results: The first bone-to-implant contact (fBIC) was located more coronally for the test implants at the first (0.065 mm (95% CI = −0.82, 0.60)) and second healing milestones (0.17 mm (95% CI = −0.9, 0.55)). Most coronal BIC of the test implants displayed a higher percentage of osseointegration, +6.33% and +13.38% after 2 and 8 weeks, respectively; however, the differences were not statistically significant. The micro-CT examination did not show any BIC difference.
Conclusions: The monophosphonate layer coating demonstrated clinical, histological, and radiographic results similar to the control surface.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Animal model, dental implants, histology, implant surface, osseointegration, monophosphonate layer, wound chamber, histometric analysis, micro-CT
Subjects:Medical sciences > Dentistry
Medical sciences > Dentistry > Dental implants
ID Code:69601
Deposited On:17 Jan 2022 13:04
Last Modified:18 Feb 2022 10:51

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