Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

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Wang, Xuejie and Villa, Carmen and Dobarganes, Yadira and Olveira, Casilda and Girón, Rosa and García Clemente, Marta and Maíz, Luis and Sibila, Oriol and Golpe, Rafael and Menéndez, Rosario and Rodríguez López, Juan Pedro and Prados, Concepción and Martinez García, Miguel Angel and Rodríguez Hermosa, Juan Luis and de la Rosa, David and Duran, Xavier and Barreiro, Esther (2021) Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study. Biomedicines, 9 (8). p. 905. ISSN 2227-9059

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Official URL: https://doi.org/10.3390/biomedicines9080905




Abstract

We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.


Item Type:Article
Uncontrolled Keywords:bronchiectasis; gender-related differences; systemic inflammation; nutritional status; biomarkers; disease severity
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Pneumology
ID Code:69643
Deposited On:03 Feb 2022 17:31
Last Modified:04 Feb 2022 08:10

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