Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication

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García Eusebi, Paulina and Sevane Fernández, Natalia and O’Rourke, Thomas and Pizarro Díaz, Manuel and Boeckx, Cedric and Dunner Boxberger, Susana (2022) Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication. Behavior Genetics . ISSN 0001-8244

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Official URL: https://doi.org/10.1007/s10519-021-10097-1



Abstract

The reactive type of aggression is regulated mostly by the brain’s prefrontal cortex; however, the molecular changes underlying aggressiveness in adults have not been fully characterized. We used an RNA-seq approach to investigate diferential gene expression in the prefrontal cortex of bovines from the aggressive Lidia breed at diferent ages: young three-year old and adult four-year-old bulls. A total of 50 up and 193 down-regulated genes in the adult group were identifed. Furthermore, a cross-species comparative analysis retrieved 29 genes in common with previous studies on aggressive behaviors, representing an above-chance overlap with the diferentially expressed genes in adult bulls. We detected changes in the regulation of networks such as synaptogenesis, involved in maintenance and refnement of synapses, and the glutamate receptor pathway, which acts as excitatory driver in aggressive responses. The reduced reactive aggression typical of domestication has been proposed to form part of a retention of juvenile traits as adults (neoteny).


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Gene expression, Prefrontal cortex, Cattle, Aggressiveness, Behavior genomics
Subjects:Medical sciences > Veterinary > Animal behavior
Medical sciences > Veterinary > Cattle
ID Code:69745
Deposited On:24 Jan 2022 12:54
Last Modified:18 Feb 2022 11:07

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