A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect

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Carballeda-Sangiao, Noelia and Chamorro Francisco, Susana and Pascual-Teresa, Sonia de (2021) A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect. Molecules, 26 (11). pp. 1-14. ISSN 1420-3049, ESSN: 1420-3049

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Official URL: https://doi.org/10.3390/molecules26113210




Abstract

Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents.


Item Type:Article
Uncontrolled Keywords:Polyphenol; Anthocyanin; Neuronal; Antioxidant; Red-berry
Subjects:Medical sciences > Biology > Neurosciences
ID Code:69755
Deposited On:24 Jan 2022 16:18
Last Modified:17 Feb 2022 12:58

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