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Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria



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Vilela García, Diana and Blanco Cabra, Nuria and Eguskiza, Ander and Hortelao, Ana C. and Torrents, Eduard and Sánchez, Samuel (2021) Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria. ACS Applied Materials & Interfaces, 13 (13). pp. 14964-14973. ISSN 1944-8244

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Official URL: https://doi.org/10.1021/acsami.1c00986


The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzymebased nanomotors for the treatment of bacterial urinary-tract infections. We develop nanomotors consisting of mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or urease and lysozyme (MMSNPs), and use them against nonpathogenic planktonic Escherichia coli. U-MSNPs exhibited the highest bactericidal activity due to biocatalysis of urea into NaHCO3 and NH3, which also propels U-MSNPs. In addition, U-MSNPs in concentrations above 200 μg/mL were capable of successfully reducing 60% of the biofilm biomass of a uropathogenic E. coli strain. This study thus provides a proof-of-concept, demonstrating that enzyme-based nanomotors are capable of fighting infectious diseases. This approach could potentially be extended to other kinds of diseases by selecting appropriate biomolecules.

Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:enzymatic nanomotors, biofilms, E. coli, infections, nanomachines, self-propulsion
Subjects:Sciences > Chemistry > Analytic chemistry
ID Code:70113
Deposited On:08 Feb 2022 15:04
Last Modified:22 Feb 2022 09:58

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