Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring

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Benito Villalvilla, Cristina and Pérez Diego, Mario and Angelina Querencias, Alba and Kisand, Kai and Rebane, Ana and Subiza, José Luis and Palomares Gracia, Oscar (2022) Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring. The Journal of Allergy and Clinical Inmunology, 149 (1). 212-222.e9. ISSN 0091-6749

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Official URL: https://doi.org/10.1016/j.jaci.2021.06.012



Abstract

Allergoid–mannan conjugates are novel vaccines for allergen-specific immunotherapy being currently assayed in phase 2 clinical trials. Allergoid–mannan conjugates target dendritic cells (DCs) and generate functional forkhead box P3 (FOXP3)-positive Treg cells, but their capacity to reprogram monocyte differentiation remains unknown.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Allergen-specific immunotherapy, allergoid–mannan conjugates, monocytes, tolerogenic dendritic cells, regulatory T cells, metabolism, epigenetics
Subjects:Sciences > Chemistry
Sciences > Chemistry > Molecular biology
Sciences > Chemistry > Biochemistry
ID Code:70115
Deposited On:08 Feb 2022 14:41
Last Modified:22 Feb 2022 09:58

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