Luminescent molecularly imprinted polymer nanocomposites for emission intensity and lifetime rapid sensing of tenuazonic acid mycotoxin

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Quílez Alburquerque, José and Descalzo López, Ana B. and Moreno Bondi, María C. and Orellana Moraleda, Guillermo (2021) Luminescent molecularly imprinted polymer nanocomposites for emission intensity and lifetime rapid sensing of tenuazonic acid mycotoxin. Polymer, 230 . p. 124041. ISSN 0032-3861

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Official URL: https://doi.org/10.1016/j.polymer.2021.124041



Abstract

Tenuazonic acid ((5S)-3-acetyl-5-[(2S)-butan-2-yl]-4-hydroxy-2,5-dihydro-1H-pyrrol-2-one, TeA) is a widespread Alternaria fungi mycotoxin in food produce. This toxin may be allergenic and provoke hay fever and asthma. Therefore, rapid methods to selectively detect TeA are needed. With this aim, we have engineered a novel trifunctional (red-luminescent, polymerizable, TeA-sensitive) ruthenium(II)-bipyridyl complex with 2,2′-biimidazole. Its peripheral N–H moieties recognize the enolate form of 1,3-dicarbonyl compounds (including TeA) in partially aqueous media. Such a binding decreases the luminescence intensity and lifetime (0.2 μs) of the Ru(II) probe. The probe also bears acrylate groups that allow radical copolymerization with methacrylamide and ethylene glycol dimethacrylate in the presence of TeA, to yield 9-nm thick luminescent molecularly imprinted polymer (MIP) shells onto 200-nm silica cores. The SiO2@Ru-MIP nanocomposite displays a very fast response (<5 s) suitable for real-time detection of TeA. No cross-sensitivity to other common food mycotoxins that also contain a β-hydroxycarbonyl moiety (alternariol, β-zeranol, cyclopiazonic acid) is observed. Detection limits of 63.8 μg L⁻1 and 75.2 μg L⁻1 under steady-state and time-resolved luminescence detection, respectively, have been measured without further optimization. The use of emission lifetime variations to monitor the levels of a target analyte has never been reported for a luminescent MIP-based sensor.


Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Luminescence, Molecularly imprinted polymers, Nanoparticles, Ruthenium(II) complexes, Tenuazonic acid
Subjects:Sciences > Chemistry
Sciences > Chemistry > Analytic chemistry
Sciences > Chemistry > Chemistry, Organic
ID Code:70119
Deposited On:08 Feb 2022 14:03
Last Modified:22 Feb 2022 09:58

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