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Bacteria-Assisted Transport of Nanomaterials to Improve Drug Delivery in Cancer Therapy



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Jiménez Jiménez, Carla and Moreno Zafra, Víctor Manuel and Vallet Regí, María (2022) Bacteria-Assisted Transport of Nanomaterials to Improve Drug Delivery in Cancer Therapy. Nanomaterials, 12 . p. 288. ISSN 2079-4991

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Official URL: https://doi.org/10.3390/nano12020288


Currently, the design of nanomaterials for the treatment of different pathologies is presenting a major impact on biomedical research. Thanks to this, nanoparticles represent a successful strat-egy for the delivery of high amounts of drugs for the treatment of cancer. Different nanosystems have been designed to combat this pathology. However, the poor penetration of these nano-materials into the tumor tissue prevents the drug from entering the inner regions of the tumor. Some bacterial strains have self-propulsion and guiding capacity thanks to their flagella. They also have a preference to accumulate in certain tumor regions due to the presence of different chemo-attractants factors. Bioconjugation reactions allow the binding of nanoparticles in living systems, such as cells or bacteria, in a simple way. Therefore, bacteria are being used as a transport vehicle for nanoparticles, facilitating their penetration and the subsequent release of the drug inside the tumor. This review would summarize the literature on the anchoring meth-ods of diverse nanosystems in bacteria and, interestingly, their advantages and possible applica-tions in cancer therapy.

Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:bacteria; nanoparticles; drug delivery; cancer; nanocarrier
Subjects:Sciences > Chemistry > Materials
ID Code:70155
Deposited On:07 Feb 2022 11:54
Last Modified:07 Feb 2022 11:54

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