Carminic Acid Linked to Silica Nanoparticles as Pigment/Antioxidant Bifunctional Excipient for Pharmaceutical Emulsions

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Arriagada, Francisco and Ugarte, Catalina and Günther, Germán and Larraín, María Angélica and Guarnizo Herrero, Victor and Nonell, Santi and Morales, Javier (2020) Carminic Acid Linked to Silica Nanoparticles as Pigment/Antioxidant Bifunctional Excipient for Pharmaceutical Emulsions. Pharmaceutics, 12 (4). p. 376. ISSN 1999-4923

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Official URL: https://doi.org/10.3390/pharmaceutics12040376



Abstract

The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant capacity of the materials, has been of great interest to the pharmaceutical, chemical and food industries. The aim of this work was to prepare and characterize a bifunctional pigment–antioxidant nanomaterial-based carminic acid-decorated solid core-mesoporous shell silica nanoparticles, evaluating its properties as a pigment, its antioxidant capacity and its properties as a chemical stabilizer of emulsions. The chemical stability of oil-in-water (O/W) Pickering emulsions was evaluated determining the stability of vitamin E solubilized in the oil phase. Carminic acid was attached through the action of coupling ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) agents, and the resulting spherical and homogeneous nanoparticles showed a diameter close to 175 nm.
A notorious change of emulsion color was observed by the addition of the nanomaterial. Emulsions showed an attractive pink color, and when the pH was adjusted to pH 3 and pH 9, a change in color was observed, analogous to carminic acid in solution. The nanomaterial incorporation also improved chemical stability, decreasing vitamin E consumption to 9.26% of the initial value, demonstrating an important antioxidant effect of the developed nanomaterial.


Item Type:Article
Uncontrolled Keywords:carminic acid; emulsion; antioxidant; silica nanoparticles; nanoexcipients
Subjects:Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:70157
Deposited On:07 Feb 2022 13:05
Last Modified:07 Feb 2022 14:57

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