Antifungal and Antiparasitic Drug Delivery

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Torrado Durán, Juan José and Serrano López, Dolores Remedios and Capilla, Javier (2020) Antifungal and Antiparasitic Drug Delivery. Pharmaceutics, 12 (4). p. 324. ISSN 1999-4923

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Official URL: https://doi.org/10.3390/pharmaceutics12040324




Abstract

Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue “Antifungal and Antiparasitic Drug Delivery”.


Item Type:Article
Uncontrolled Keywords:: liposomes; transferosomes; nanoparticles; emulsions; candidiasis; aspergillosis; azoles; amphotericin B; combined therapy; quality by design; eishmaniasis; malaria; trypanosomiasis
Subjects:Medical sciences > Pharmacy > Pharmacology
Medical sciences > Pharmacy > Food technology
ID Code:70306
Deposited On:10 Feb 2022 13:50
Last Modified:11 Feb 2022 11:38

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