Publication: Geometrical limits for UV-C inactivation of pathogens
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2022-10-30
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Elsevier
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Abstract
The inactivation of pathogens through the irradiation of ultraviolet light depends on how light propagates within the medium where the microorganism is immersed. A simple geometrical optics analysis, and a fluence evaluation reveal some reservoirs where the pathogen may hide and be weakly exposed to the incoming radiation. This geometrical hide-outs also generate a tail in the plot of the total inactivation plot vs. the incoming fluence. We have analyzed these facts using geometrical optics principles and illumination engineering computational packages. The results obtained from previous biomedical measurements involving SARS-CoV-2 have been used to evaluate the inactivation degree for an spherical geometry applicable to airborne pathogens, and for an spherical cap geometry similar to that used in biomedical experiments. The case presented here can be seen as the worst-case scenario applicable under collimated illumination.
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CRUE-CSIC (Acuerdos Transformativos 2021)