Matrix tablets based on a novel poly (magnesium acrylate) hydrogel for the treatment of inflammatory bowel diseases

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Simancas Herbada, Rebeca and Torres Suárez, Ana Isabel and Otero Espinar, Francisco and Fraguas Sánchez, Ana Isabel and López Cabarcos, Enrique and Rubio Retama, Jorge and Fernández Carballido, Ana María (2021) Matrix tablets based on a novel poly (magnesium acrylate) hydrogel for the treatment of inflammatory bowel diseases. International journal of pharmaceutics, 608 . p. 121121. ISSN 0378-5173

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Official URL: https://doi.org/10.1016/j.ijpharm.2021.121121




Abstract

The objective of this work was to evaluate the potential use of a new polymer (PAMgA) in the development sustained release matrix tablets for the treatment of bowel inflammatory diseases. For this purpose, budesonide, a highly lipophilic compound, was used as model drug. Tablets with two reticulation grades of PAMgA (PAMgA 5 and 40) and with 9 mg of budesonide were developed and characterized. All the studies were carried out using biorelevant media (FaSSGF and FaSSIF). Swelling and erosion of PAMgA tablets was influenced by the reticulation grade of the polymer and the biorelevant media assayed, being water uptake higher for PAMgA 40 tablets in intestinal fluid, whereas PAMgA 5 showed more intense erosion in this biorelevant medium. Budesonide was released slowly from PAMgA tablets, both in gastric and intestinal environment, following Super case II transport kinetics (relaxation-controlled delivery), with a lag time of around 1–2 h. When the dissolution medium was changed sequentially throughout the trial, 75% of the budesonide dose was released in a sustained manner between 4 and 20 h of testing from PAMgA tablets, showing a more controlled budesonide release than Entocort® and Budenofalk® (commercially available sustained release formulations of budesonide). In conclusion, PAMgA polymer allows controlling the release of highly lipophilic drugs as budesonide, being an useful excipient for the development of sustained release matrix tablets.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Bioadhesion; Budesonide; Hydrogel; Inflammatory bowel diseases; Matrix tablets; Poly (magnesium acrylate)
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:70411
Deposited On:14 Feb 2022 08:54
Last Modified:21 Feb 2022 15:02

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