Premature aging in chronic kidney disease: the outcome of persistent inflammation beyond the bounds



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Figuer, Andrea and Bodega, Guillermo and Tato, Patricia and Valera, Gemma and Serroukh Mansouri, Nadia and Ceprián, Noemí and Sequera Ortiz, Patricia de and Morales Ruiz, Enrique and Carracedo Añón, Julia María and Ramírez, Rafael and Alique, Matilde (2021) Premature aging in chronic kidney disease: the outcome of persistent inflammation beyond the bounds. International Journal of Environmental Research and Public Health, 18 (15). pp. 1-16. ISSN 1661-7827, ESSN: 1660-4601

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Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversible physiological changes associated with loss of functional, psychological, and social capabilities. Numerous factors, such as oxidative stress, inflammation, and cellular senescence, and an irreversible geriatric syndrome known as frailty, contribute to human body deterioration in aging. The speed of aging may differ between individuals depending on the presence or absence of multiple factors (genetic and/or environment) and the subsequent misbalance of homeostasis, together with the increase of frailty, which also plays a key role in developing chronic diseases. In addition, pathological circumstances have been reported to precipitate or accelerate the aging process. This review investigated the mechanisms involved in the developing pathologies, particularly chronic kidney disease, associated with aging.

Item Type:Article
Uncontrolled Keywords:Aging; Cellular senescence; Chronic kidney disease; Elderly; Frailty; Oxidative stress
Subjects:Medical sciences > Medicine > Physiology
Medical sciences > Medicine > Nephrology and Urology
ID Code:70429
Deposited On:14 Feb 2022 15:05
Last Modified:07 Mar 2022 15:09

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