Bigels as drug delivery systems: From their components to their applications

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Martín Illana, Araceli and Notario Pérez, Fernando and Cazorla Luna, Raúl and Ruiz Caro, Roberto and Bonferoni, Maria C. and Tamayo, Aitana and Veiga Ochoa, María Dolores (2021) Bigels as drug delivery systems: From their components to their applications. Drug Discovery Today . ISSN 1359-6446

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Official URL: https://doi.org/10.1016/j.drudis.2021.12.011



Abstract

Bigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent in each phase, the organogel/hydrogel ratio, and the mixing temperature and speed all need to be taken into consideration for bigel manufacturing. Bigels, which are particularly useful drug delivery systems, have already been formulated for transdermal, buccal, and vaginal routes. Mechanical assessments and microscopy are the most reported characterization techniques. As we review here, their composition and unique structure confer promising drug delivery attributes, such as mucoadhesion, the ability to control drug release, and the possibility of including both hydrophilic and lipophilic drugs in the same system.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2021)

Uncontrolled Keywords:Hydrogel; Organogel; Organogelator; Bigel manufacturing; Bigel characterization; Drug delivery bigels
Subjects:Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:70496
Deposited On:16 Feb 2022 10:32
Last Modified:21 Feb 2022 15:25

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