Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw



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Bacián Martínez, Sandra and Navarro Cuéllar, Carlos and Navarro Vila, Carlos and Palacios Weiss, Edurne and Pujol Romanyá, Roser and Amo Fernández de Velasco, Álvaro del and Escrig de Teijeiro, Margarita and Castillo Pardo de Vera, José Luis del and Rodríguez Pérez, Irene and Sánchez-Pérez, Arturo and Zamorano León, José Javier and López Farré, Antonio José and García-Hidalgo Alonso, María Isabel and Navarro Cuéllar, Ignacio (2021) Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw. Applied Sciences, 11 (16). p. 7646. ISSN 2076-3417

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Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.

Item Type:Article
Uncontrolled Keywords:denosumab; medication related osteonecrosis of the jaw (MRNOJ); primary intraosseous squamous cell carcinoma
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Dentistry
ID Code:70749
Deposited On:24 Feb 2022 14:35
Last Modified:25 Feb 2022 09:06

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