Genomic Plasticity of Vibrio cholerae.



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Escudero García-Calderón, José Antonio and Mazel, Didier (2017) Genomic Plasticity of Vibrio cholerae. International microbiology : the official journal of the Spanish Society for Microbiology, 20 (3). pp. 138-148. ISSN 1139-6709

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Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, a disease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. cholerae is a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insects and crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. In this review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of its genome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-cost memory of adaptive functions, allowing V. cholerae to adapt rapidly.

Item Type:Article
Uncontrolled Keywords:vibrio cholerae, genome plasticity, superintegron
Subjects:Medical sciences > Medicine
Medical sciences > Medicine > Medical microbiology
Medical sciences > Veterinary
Medical sciences > Veterinary > Microbiology
Medical sciences > Biology > Molecular biology
Medical sciences > Biology > Ecology
Medical sciences > Biology > Microbiology
ID Code:70813
Deposited On:28 Feb 2022 11:17
Last Modified:04 Apr 2022 15:15

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