Keratoconus: An updated review

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Santodomingo Rubido, Jacinto and Carracedo Rodríguez, Juan Gonzalo and Suzaki, Asaki and Villa Collar, César and Vincent, Stephen J. and Wolffsohn, James S. (2022) Keratoconus: An updated review. Contact Lens and Anterior Eye, 45 (3). p. 101559. ISSN 1367-0484

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Official URL: https://doi.org/10.1016/j.clae.2021.101559




Abstract

Keratoconus is a bilateral and asymmetric disease which results in progressive thinning and steeping of the cornea leading to irregular astigmatism and decreased visual acuity. Traditionally, the condition has been described as a noninflammatory disease; however, more recently it has been associated with ocular inflammation. Keratoconus normally develops in the second and third decades of life and progresses until the fourth decade. The condition affects all ethnicities and both sexes. The prevalence and incidence rates of keratoconus have been estimated to be between 0.2 and 4,790 per 100,000 persons and 1.5 and 25 cases per 100,000 persons/year, respectively, with highest rates typically occurring in 20- to 30-year-olds and Middle Eastern and Asian ethnicities. Progressive stromal thinning, rupture of the anterior limiting membrane, and subsequent ectasia of the central/paracentral cornea are the most commonly observed histopathological findings. A family history of keratoconus, eye rubbing, eczema, asthma, and allergy are risk factors for developing keratoconus. Detecting keratoconus in its earliest stages remains a challenge. Corneal topography is the primary diagnostic tool for keratoconus detection. In incipient cases, however, the use of a single parameter to diagnose keratoconus is insufficient, and in addition to corneal topography, corneal pachymetry and higher order aberration data are now commonly used. Keratoconus severity and progression may be classified based on morphological features and disease evolution,ocular signs, and index-based systems. Keratoconus treatment varies depending on disease severity and progression. Mild cases are typically treated with spectacles, moderate cases with contact lenses, while severe cases that cannot be managed with scleral contact lenses may require corneal surgery. Mild to moderate cases of progressive keratoconus may also be treated surgically, most commonly with corneal cross-linking. This article provides an updated review on the definition, epidemiology, histopathology, aetiology and pathogenesis, clinical features, detection, classification, and management and treatment strategies for keratoconus.


Item Type:Article
Additional Information:

Received 19 August 2021, Revised 23 November 2021, Accepted 12 December 2021, Available online 4 January 2022, Version of Record 14 May 2022.

Uncontrolled Keywords:Epidemiology; ; Detection; Classification; Histopathology; Aetiology; Management
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Low vision
Medical sciences > Optics > Physiological optics
ID Code:70919
Deposited On:27 Jul 2022 10:23
Last Modified:03 Aug 2022 10:34

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