Publication: Sistemas de liberación modificada para la administración de fármacos mediante la vía tópica ocular en patologías del segmento anterior
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2020-09
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Abstract
La falta de adherencia por parte del paciente en el campo de la administración de fármacos por vía oftálmica, ha llevado a la búsqueda de nuevos sistemas, gracias a los cuales, por diferentes mecanismos, consiguen que el fármaco permanezca durante periodos más prolongados de tiempo en la superficie ocular, haciendo de esta manera que se necesite un menor número de aplicaciones. A esto hay que añadir la ventaja de conseguir, en determinados casos, una liberación más sostenida de los principios activos. Gracias al desarrollo de estos sistemas, se pretende conseguir un mayor cumplimiento, así como una mayor eficacia. En este trabajo, a través de una revisión, nos centraremos especialmente en los liposomas, dendrímeros e hidrogeles. Tres sistemas en pleno desarrollo tecnológico que suponen un avance en el campo de la farmacología ocular.
Considering the lack of adhesion present in the majority of the patients who use eye drops, it has been developed new pharmaceutical systems with the objective to achieve that the medicine remain longer periods of time on the eye surface with diminishing the number of administrations, and also, being capable to get a controlled drug delivery in the eye. With all of this, it can be increased the therapeutic compliance, as well as to obtain a higher efficacy of the ophthalmic formulation. In this project, through a bibliographic review, we will focus on liposomes, dendrimers and hidrogels. These three pharmaceutical systems in fully technological development mean to be a whole strategy on reference to the field of ocular pharmacotherapy in the future.
Considering the lack of adhesion present in the majority of the patients who use eye drops, it has been developed new pharmaceutical systems with the objective to achieve that the medicine remain longer periods of time on the eye surface with diminishing the number of administrations, and also, being capable to get a controlled drug delivery in the eye. With all of this, it can be increased the therapeutic compliance, as well as to obtain a higher efficacy of the ophthalmic formulation. In this project, through a bibliographic review, we will focus on liposomes, dendrimers and hidrogels. These three pharmaceutical systems in fully technological development mean to be a whole strategy on reference to the field of ocular pharmacotherapy in the future.