Effect of COVID-19 lockdown in Spain on structural and functional outcomes of Neovascular AMD patients



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Valverde Megías, Alicia and Rego Lorca, Daniela and Fernández Vigo, José Ignacio and Murciano Cespedosa, Antonio and Megías Fresno, Alicia and García Feijoo, Julián (2021) Effect of COVID-19 lockdown in Spain on structural and functional outcomes of Neovascular AMD patients. Journal of Clinical Medicine, 10 (6). pp. 1-11. ISSN Electronic: 2077-0383

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Official URL: https://doi.org/10.3390/jcm10163551


This is a retrospective single-center study of patients with neovascular age-related macular degeneration whose follow-up was delayed due to COVID-19 pandemic with at least three months between visits in Madrid, Spain. The purpose of the study was to evaluate best corrected visual acuity (BCVA) changes and try to identify features in optical coherence tomography (OCT) that could be related to more profound visual loss. It included 270 eyes. The two last visits before lockdown were used for comparison with the visit after lockdown. BCVA changed from 60.2 ± 18.2 to 55.9 ± 20.5 ETDRS letters. 29% of the eyes lost more than 5 letters. OCT was active in 67% of eyes before lockdown and in 80.4% after lockdown. Multiple lineal analysis showed that patients whose OCT before lockdown presented with a combination of intra and subretinal fluid were more likely to suffer a greater visual loss (p = 0.002). These patients should be encouraged to not miss any visits in case a new lockdown is imposed.

Item Type:Article
Uncontrolled Keywords:COVID-19; nAMD; anti-VEGF
Subjects:Medical sciences > Medicine > Communicable diseases
Medical sciences > Medicine > Ophtalmology
ID Code:71031
Deposited On:08 Mar 2022 11:39
Last Modified:08 Mar 2022 12:45

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