Female mice reaching exceptionally high old age have preserved 20S proteasome activities

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Martínez de Toda Cabeza, Irene and Rattan, Suresh I. S. and Fuente del Rey, Mónica de la and Arranz Salas, Lorena (2021) Female mice reaching exceptionally high old age have preserved 20S proteasome activities. Antioxidants, 10 (9). pp. 1-9. ISSN Electronic: 2076-3921

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Official URL: https://doi.org/10.3390/antiox10091397




Abstract

Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on the tissue or cell type and it is unknown how the 20S proteasome functions in exceptionally old mice. The aim of this study was to investigate two proteasome activities (caspase-like and chymotrypsin-like) in several tissues (lung, heart, axillary lymph nodes, liver, kidney) and cells (peritoneal leukocytes) from adult (28 ± 4 weeks, n = 12), old (76 ± 4 weeks, n = 9) and exceptionally old (128 ± 4 weeks, n = 9) BALB/c female mice. The results show different age-related changes depending on the tissue and the activity considered, so there is no universal decline in proteasome function with age in female mice. Interestingly, exceptionally old mice displayed better maintained proteasome activities, suggesting that preserved 20S proteasome is associated with successful aging.


Item Type:Article
Uncontrolled Keywords:Aging; Healthy aging; Exceptionally old; 20S proteasome; Caspase-like activity; Chymotrypsinlike activity
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Biochemistry
Medical sciences > Biology > Animal physiology
ID Code:71054
Deposited On:09 Mar 2022 09:02
Last Modified:09 Mar 2022 15:42

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