Publication: Nuevas estrategias sintéticas estereocontroladas basadas en lactamas y alenos : aplicación a la preparación de heterociclos potencialmente bioactivos
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2022-03-10
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Universidad Complutense de Madrid
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Abstract
Los alenos desde su descubrimiento se han considerado como un grupo particular en Química Orgánica. En comparación con la química de grupos funcionales análogos, como los alquenos o alquinos, este tipo de compuestos han captado una menor atención de los grupos de investigación. Los alenos son capaces de mostrar reactividad frente a diversos sustratos, siendo las reacciones más comunes las de carbociclación y heterociclación catalizadas por metales de transición. De este modo, se ha logrado el acceso a compuestos con alto interés químico y biológico. Por otro lado, los alquinos son uno de los grupos funcionales más estudiados en Química Orgánica. Desde 2014, la catálisis foto-redox que involucra alquinos y sales de diazonio ha sido ampliamente estudiada. Las reacciones promovidas por moléculas orgánicas como son el ácido gálico, el ácido L-ascórbico o el 1,2,3-bencenotriol generan nuevos acoplamientos y evitan el uso de metales de transición...
Since their discovery, allenes have been identified as an unusual structure in Organic Chemistry. Allenes are capable of showing reactivity to various substrates but these types of compounds have attracted less attention from research groups incomparison with the chemistry of analogous functional groups such as alkenes oralkynes. Carbocyclization and heterocyclization reactions catalyzed by transition metals are the most common rearrangement. In this manner, compounds with chemical and biological interest have been achieved. On the other hand, alkynes are one of the most versatile functional groups in Organic Chemistry. Since 2014, photoredox catalysis between alkynes and diazonium salts has received significant attention. The use of organic promoters such as gallic acid, L-ascorbic acid or 1,2,3-triolbenzene, is continuously growing in order to avoid the toxicity of transition metals...
Since their discovery, allenes have been identified as an unusual structure in Organic Chemistry. Allenes are capable of showing reactivity to various substrates but these types of compounds have attracted less attention from research groups incomparison with the chemistry of analogous functional groups such as alkenes oralkynes. Carbocyclization and heterocyclization reactions catalyzed by transition metals are the most common rearrangement. In this manner, compounds with chemical and biological interest have been achieved. On the other hand, alkynes are one of the most versatile functional groups in Organic Chemistry. Since 2014, photoredox catalysis between alkynes and diazonium salts has received significant attention. The use of organic promoters such as gallic acid, L-ascorbic acid or 1,2,3-triolbenzene, is continuously growing in order to avoid the toxicity of transition metals...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, Departamento de Química Orgánica, leída el 24-09-2021