New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

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García Martínez, Antonio and Herrera Fernández, Antonio and Moreno Jiménez, Florencio and Muñoz Martínez, Pablo J. and Alonso Martín, Cristina and Subramanian, Laksminarayanapuran R. (1996) New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines. Tetrahedron, 52 (23). pp. 7973-7982. ISSN 0040-4020

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Official URL: https://doi.org/10.1016/0040-4020(96)00368-7



Abstract

N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2,4 Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.


Item Type:Article
Additional Information:

Received in UK 15 March 1996; revised 2 April 1996; accepted 12 April 1996

Uncontrolled Keywords:Heterocyclic synthesis; heteroarylpyrimidines.
Subjects:Sciences > Chemistry > Chemistry, Organic
ID Code:71217
Deposited On:15 Sep 2022 17:40
Last Modified:16 Sep 2022 07:51

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