Publication: New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines
Loading...
Official URL
Full text at PDC
Publication Date
1996-06-03
Authors
García Martínez, Antonio
Muñoz Martínez, Pablo J.
Alonso Martín, Cristina
Subramanian, Laksminarayanapuran R.
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Citations
Exportar
Abstract
N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2,4 Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.
Description
Received in UK 15 March 1996; revised 2 April 1996; accepted 12 April 1996