Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis



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Rapado Castro, Marta and Villar Arenzana, Mara and Janssen, Joost and Fraguas Herráez, David and Bombin, Igor and Castro Fornieles, Josefina and Mayoral, Maria and González Pinto, Ana and Serna, Elena de la and Parellada, Mara and Moreno, Dolores and Paya, Beatriz and Graell, Montserrat and Baeza, Inmaculada and Pantelis, Christos and Arango, Celso (2021) Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis. Journal of Clinical Medicine, 10 (17). p. 3929. ISSN 2077-0383

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Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, p = 0.008); right (B = 0.089, p = 0.015); parietal left (B = 0.119, p = 0.007), right (B = 0.125, p = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group.

Item Type:Article
Uncontrolled Keywords:working memory; attention; executive function; early onset psychosis; brain volume; adolescence; gray matter; magnetic resonance imaging; MRI
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Psychiatry
Medical sciences > Psychology
ID Code:71286
Deposited On:25 Mar 2022 14:56
Last Modified:26 Mar 2022 12:38

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