Sex-Related Disparities in the Incidence and Outcomes of Community-Acquired Pneumonia among Type 2 Diabetes Patients: A Propensity Score-Matching Analysis Using the Spanish National Hospital Discharge Database for the Period 2016–2019

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López de Andrés, Ana and Jiménez García, Rodrigo and Hernández Barrera, Valentín and Miguel Díez, Javier de and Miguel Yanes, José María de and Carabantes Alarcón, David and Zamorano León, José Javier and Sanz Rojo, Sara and López Herranz, Marta (2021) Sex-Related Disparities in the Incidence and Outcomes of Community-Acquired Pneumonia among Type 2 Diabetes Patients: A Propensity Score-Matching Analysis Using the Spanish National Hospital Discharge Database for the Period 2016–2019. Journal of Clinical Medicine, 10 (17). p. 3975. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm10173975



Abstract

(1) Background: To analyze incidence, clinical characteristics, procedures, and in-hospital outcomes among patients hospitalized with community-acquired pneumonia (CAP) according to the presence of T2DM in Spain (2016–2019) and to assess the role of gender among those with T2DM.
(2) Methods: Using the Spanish National Hospital Discharge Database, we estimated hospitalized CAP incidence. Propensity score matching was used to compare population subgroups.
(3) Results: CAP was coded in 520,723 patients, of whom 140,410 (26.96%) had T2DM. The hospitalized CAP incidence was higher in patients with T2DM (both sexes) (IRR 4.25; 95% CI 4.23–4.28). The hospitalized CAP incidence was higher in men with T2DM than in women with T2DM (IRR 1.46; 95% CI 1.45–1.47). The hospitalized CAP incidence among T2DM patients increased over time; however, the in-hospital mortality (IHM) decreased between 2016 and 2019. IHM was higher among non-T2DM men and women than matched T2DM men and women (14.23% and 14.22% vs. 12.13% and 12.91%; all p < 0.001, respectively), After adjusting for confounders, men with T2DM had a 6% higher mortality risk than women (OR 1.06; 95% CI 1.02–1.1).
(4) Conclusions: T2DM is associated with a higher hospitalized CAP incidence and is increasing overtime. Patients hospitalized with CAP and T2DM have lower IHM. Male sex is a significant risk factor for mortality after CAP among T2DM patients.


Item Type:Article
Uncontrolled Keywords:community-acquired pneumonia; type 2 diabetes mellitus; hospitalizations; outcomes
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Pneumology
Medical sciences > Medicine > Public health
ID Code:71287
Deposited On:25 Mar 2022 14:36
Last Modified:26 Mar 2022 12:15

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