Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure

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Vicent, Lourdes and Guerra, Jose and Vazquez García, Rafael and Gonzalez Juanatey, José R. and Dolz, Luis Martínez and Segovia, Javier and Pascual Figal, Domingo and Bover, Ramón and Worner, Fernando and Delgado, Juan and Fernández-Avilés Díaz, Francisco and Martínez Sellés d'Oliveira Soares, Manuel (2021) Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure. Journal of Clinical Medicine, 10 (8). p. 1713. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm10081713




Abstract

Coronary heart disease is common in heart failure (HF). Our aim was to determine the impact of ischemic etiology on prognosis among men and women with HF. This study is a prospective national multicenter registry. The primary endpoint was 12-month mortality. Patients with HF and ischemic heart disease were stratified according to sex. A total of 1830 patients were enrolled of which 756 (41.3%) were women. Ischemic etiology was more common in men (446 (41.6%)) than in women (167 (22.2%)). Among patients with ischemic HF, diabetes was more frequent in women than in men. Ischemic etiology was not associated with higher mortality risk, and this was true for women (Hazard Ratio [HR] 1.51, 95% Confidence Interval [CI] 0.98–2.32; p = 0.61) and men (HR 1.14, 95% CI 0.81–1.61; p = 0.46), p-value for interaction: 0.067. Mortality/readmission risk in ischemic HF increased in men with previous readmissions (HR 1.15, 95% CI 1.02–1.29; p = 0.022), chronic obstructive pulmonary disease (HR1.20, 95% CI 1.02–1.41; p = 0.026) and in women with diabetes (HR 2.23, 95% CI 1.05–4.47; p = 0.035). Ischemic etiology was not associated with mortality in HF patients. In ischemic HF, the variables associated with a poor prognosis were diabetes in women and previous readmissions and chronic obstructive pulmonary disease in men.


Item Type:Article
Uncontrolled Keywords:heart failure; mortality; ischemic heart disease
Subjects:Medical sciences > Medicine > Cardiology
ID Code:71306
Deposited On:31 Mar 2022 14:44
Last Modified:31 Mar 2022 15:16

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