The Influence of Multidrug-Resistant Bacteria on Clinical Outcomes of Diabetic Foot Ulcers: A Systematic Review



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Matta Gutiérrez, Gianmarco and García Morales, Esther Alicia and García Álvarez, Yolanda and Álvaro Afonso, Francisco Javier and Molines Barroso, Raúl Juan and Lázaro Martínez, José Luis (2021) The Influence of Multidrug-Resistant Bacteria on Clinical Outcomes of Diabetic Foot Ulcers: A Systematic Review. Journal of Clinical Medicine, 10 (9). p. 1948. ISSN 2077-0383

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Multidrug-resistant organism infections have become important in recent years due to the increased prevalence of diabetic foot ulcers and their possible consequences. This study aimed to systematically review and evaluate ulcer duration, healing time, hospital stay, amputation, and mortality rates in patients with diabetic foot ulcers caused by infection with multidrug-resistant organisms. PubMed, the Cochrane Library, and Web of Science were searched in May 2020 to find observational studies in English about the clinical outcomes of multidrug-resistant organism infection in diabetic foot ulcers. Eight studies met the inclusion criteria, and these studies included 923 patients. The overall methodological quality of the study was moderate. Ulcer duration was described in six studies, and there was no practical association with multidrug-resistant organisms. Two out of three studies reported a longer healing time in multidrug-resistant organism infections than in non-multidrug-resistant organism infections. Clinical outcomes included the duration of hospitalisation, surgeries, amputations, and deaths. Lower limb amputation was the most reported clinical outcome in the included studies, and was more prevalent in the multidrug-resistant organism infections. We concluded that there was not enough evidence that multidrug-resistant organisms hindered the healing of diabetic foot ulcers. In contrast to the clinical outcomes, multidrug-resistant organisms affect both amputation rates and mortality rates.

Item Type:Article
Uncontrolled Keywords:diabetic foot; foot infection; multidrug-resistant organisms; amputation; systematic review
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Nursing > Podiatry
ID Code:71313
Deposited On:18 Mar 2022 09:23
Last Modified:18 Mar 2022 09:44

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