Lanthanide doped nanoheaters with reliable and absolute temperature feedback

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López Peña, Gabriel and Hamraoui, Khouloud and Horchan -Naifer, Karima and Gerke, Christoph and Ortgies, Dirk H. and Martín Rodríguez, Emma and Chen, Guanying and Jaque García, Daniel and Rubio Retama, Jorge (2022) Lanthanide doped nanoheaters with reliable and absolute temperature feedback. Physica B: Condensed Matter, 631 . p. 413652. ISSN 09214526

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Official URL: https://doi.org/10.1016/j.physb.2021.413652



Abstract

The development of selective and controlled photo-thermal therapies requires luminescent nanoparticles capable of simultaneous heating and contactless thermal sensing. Until now, thermal therapies have suffered from a lack of control over the absolute temperature of the treated tissue because the nanothermometers used for thermal feedback, based on a spectral analysis of emitted radiation, were affected by the inhomogeneous extinction of the tissues. This work shows how this deficiency can be overcome by using core-shell-shell nanostructures doped with lanthanide ions (Nd3+ and Yb3+). Thermal reading was achieved from the analysis of the Yb3+ luminescence lifetime whereas simultaneous heating was achieved thanks to the non-radiative deexcitations of Nd3+ ions. Simple proof-of-concept experiments show the great potential of these lanthanide-doped nanostructures for the development of in vivo photo-thermal treatments with absolute and reliable thermal feedback.


Item Type:Article
Uncontrolled Keywords:Lanthanide-doped nanoparticles, Photothermal therapy, Luminescence nanothermometry, Temperature, Lifetime
Subjects:Sciences > Chemistry > Materials
ID Code:71640
Deposited On:04 Apr 2022 10:45
Last Modified:04 Apr 2022 10:50

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