Determinants of HIV-1 Late Presentation in Patients Followed in Europe

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Miranda, Mafalda N. S. and Pingarilho, Marta and Pimentel, Victor and Martins, Maria do Rosário O. and Vandamme, Anne-Mieke and Bobkova, Marina and Böhm, Michael and Seguin Devaux, Carole and Paredes, Roger and Rubio García, Rafael and Zazzi, Maurizio and Incardona, Francesca and Abecasis, Ana (2021) Determinants of HIV-1 Late Presentation in Patients Followed in Europe. Pathogens, 10 (7). p. 835. ISSN 2076-0817

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Official URL: https://doi.org/10.3390/pathogens10070835




Abstract

To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89,851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmission, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.


Item Type:Article
Uncontrolled Keywords:HIV-1 infection; late presentation; Europe
Subjects:Medical sciences > Medicine > Immunology
ID Code:71652
Deposited On:22 Apr 2022 13:25
Last Modified:25 Apr 2022 07:58

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