Early Appearance of Epicardial Adipose Tissue through Human Development



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Pérez Miguelsanz, Juliana and Jiménez Ortega, Vanesa and Cano Barquilla, Pilar and Garaulet, Marta and Esquifino, Ana I. and Varela Moreiras, Gregorio and Fernández Mateos, Pilar (2021) Early Appearance of Epicardial Adipose Tissue through Human Development. Nutrients, 13 (9). p. 2906. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu13092906


Background: Epicardial adipose tissue (EAT) is a visceral fat depot with unique anatomic, biomolecular and genetic features. Due to its proximity to the coronary arteries and myocardium, dysfunctional EAT may contribute to the development and progression of cardiovascular and metabolic-related adiposity-based chronic diseases. The aim of this work was to describe, by morphological techniques, the early origin of EAT.
Methods: EAT adipogenesis was studied in 41 embryos from 32 gestational days (GD) to 8 gestational weeks (GW) and in 23 fetuses until full term (from 9 to 36 GW).
Results: This process comprises five stages. Stage 1 appears as mesenchyme at 33–35 GD. Stage 2 is characterized by angiogenesis at 42–45 GD. Stage 3 covers up to 34 GW with the appearance of small fibers in the extracellular matrix. Stage 4 is visible around the coronary arteries, as multilocular adipocytes in primitive fat lobules, and Stage 5 is present with unilocular adipocytes in the definitive fat lobules. EAT precursor tissue appears as early as the end of the first gestational month in the atrioventricular grooves. Unilocular adipocytes appear at the eighth gestational month.
Conclusions: Due to its early origin, plasticity and clinical implications, factors such as maternal health and nutrition might influence EAT early development in consequence.

Item Type:Article
Uncontrolled Keywords:epicardial adipose tissue development; coronary arteries; human embryo and fetus; cardiovascular disease; metabolic fetal programing
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Gynecology and Obstetrics
Medical sciences > Nursing > Nutrition
Medical sciences > Nursing > Dietetics
ID Code:71655
Deposited On:22 Apr 2022 13:25
Last Modified:25 Apr 2022 07:52

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