Diabetes Mellitus and Its Implications in Aortic Stenosis Patients



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Mouriño Álvarez, Laura and Corbacho Alonso, Nerea and Sastre Oliva, Tamara and Corros Vicente, Cecilia and Solis, Jorge and Tejerina Sánchez, Teresa and Padial, Luis R. and Barderas, Maria G. (2021) Diabetes Mellitus and Its Implications in Aortic Stenosis Patients. International Journal of Molecular Sciences, 22 (12). p. 6212. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms22126212


Aortic stenosis (AS) and diabetes mellitus (DM) are both progressive diseases that if left untreated, result in significant morbidity and mortality. Several studies revealed that the prevalence of DM is substantially higher in patients with AS and, thus, the progression from mild to severe AS is greater in those patients with DM. DM and common comorbidities associated with both diseases, DM and AS, increase patient management complexity and make aortic valve replacement the only effective treatment. For that reason, a better understanding of the pathogenesis underlying both these diseases and the relationships between them is necessary to design more appropriate preventive and therapeutic approaches. In this review, we provided an overview of the main aspects of the relationship between AS and DM, including common comorbidities and risk factors. We also discuss the established treatments/therapies in patients with AS and DM.

Item Type:Article
Uncontrolled Keywords:diabetes mellitus; aortic stenosis; calcification; risk prediction
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Hematology
ID Code:71665
Deposited On:19 Apr 2022 15:11
Last Modified:20 Apr 2022 07:28

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