Increased individual homozygosity is correlated with low fitness in a fragmented lizard population

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Pérez Tris, Javier and Llanos Garrido, Alejandro and Bloor, Paul and Carbonell Alanís, Roberto and Tellería Jorge, José Luis and Santos Martínez, Tomás and Díaz González-Serrano, José A. (2019) Increased individual homozygosity is correlated with low fitness in a fragmented lizard population. Biological Journal of the Linnean Society, 128 (4). pp. 952-962. ISSN 0024-4066, Electronic: 1095-8312

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Official URL: https://doi.org/10.1093/biolinnean%2Fblz144




Abstract

Isolation owing to anthropogenic habitat fragmentation is expected to increase the homozygosity of individuals, which might reduce their fitness as a result of inbreeding depression. Using samples from a fragmented population of the lizard Psammodromus algirus, for which we had data about two correlates of fitness, we genotyped individuals for six microsatellite loci that correctly capture genome-wide individual homozygosity of these lizards (as validated with an independent sample of lizards genotyped for both these microsatellites and > 70 000 single nucleotide polymorphisms). Our data revealed genetic structure at a very small geographical scale, which was compatible with restricted gene flow among populations disconnected in a matrix of inhospitable habitat. Lizards from the same fragment were genetically more related to one another than expected by chance, and individual homozygosity was greater in small than in large fragments. Within fragments, individual homozygosity was negatively associated with adult body size and clutch mass, revealing a link among reduced gene flow, increased homozygosity and lowered fitness that might reduce population viability deterministically. Our results contribute to mounting evidence of the impact of the loss of genetic diversity on fragmented wild populations.


Item Type:Article
Uncontrolled Keywords:Body size; Breeding investment; Genetic relatedness; Habitat fragmentation; Homozygosity; Psammodromus algirus
Subjects:Medical sciences > Biology > Ecology
Medical sciences > Biology > Evolution
Medical sciences > Biology > Genetics
Medical sciences > Biology > Reptiles
Medical sciences > Biology > Zoology
ID Code:71744
Deposited On:19 Apr 2022 10:47
Last Modified:14 Oct 2022 08:14

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