Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice

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Vega Martín, Elena and Gil Ortega, Marta and González Blázquez, Raquel and Benedito Castellote, Sara and Fernández Felipe, Jesús and Ruiz Gayo, Mariano and Olmo, Nuria del and Chowen, Julie A. and Frago, Laura M. and Somoza, Beatriz and Fernández Alfonso, María Soledad (2021) Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice. Nutrients, 13 (3). p. 1003. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu13031003




Abstract

Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high-oleic-acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans-fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA-enriched high-fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five-week-old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil-enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil-enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the β-index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity-related vascular alterations that is exacerbated by SFA.


Item Type:Article
Uncontrolled Keywords:Saturated fatty acids; Monounsaturated fatty acids; Purified high-fat diets; Endothelial dysfunction; Nitric oxide; Vascular remodeling; Arterial stiffness; Collagen
Subjects:Medical sciences > Pharmacy > Dietetics and nutrition
Medical sciences > Pharmacy > Pharmacology
ID Code:71840
Deposited On:21 Apr 2022 09:35
Last Modified:21 Apr 2022 10:30

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