Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices



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Cicuéndez, Mónica and Casarrubios, Laura and Feito Castellano, María José and Madarieta, Iratxe and Garcia-Urkia, Nerea and Murua, Olatz and Olalde, Beatriz and Briz, Nerea and Díez Orejas, Rosalía and Portolés Pérez, María Teresa (2021) Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices. Journal of Fungi, 7 (5). p. 392. ISSN 2309-608X

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Macrophages, cells effective in sensing, internalizing and killing Candida albicans, are intertwined with the extracellular matrix (ECM) through different signals, which include the release of specific cytokines. Due to the importance of these interactions, the employment of in vitro models mimicking a fungal infection scenario is essential to evaluate the ECM effects on the macrophage response. In this work, we have analyzed the effects of human and porcine decellularized adipose matrices (DAMs), obtained by either enzymatic or organic solvent treatment, on the macrophage/Candida albicans interface. The present study has allowed us to detect differences on the activation of macrophages cultured on either human- or porcine-derived DAMs, evidencing changes in the macrophage actin cytoskeleton, such as distinct F-actin-rich membrane structures to surround the pathogen. The macrophage morphological changes observed on these four DAMs are key to understand the defense capability of these cells against this fungal pathogen. This work has contributed to the knowledge of the influence that the extracellular matrix and its components can exert on macrophage metabolism, immunocompetence and capacity to respond to the microenvironment in a possible infection scenario.

Item Type:Article
Uncontrolled Keywords:Candida albicans; Macrophage; Extracellular matrix; Decellularization; Immunocompetence; Phagocytosis
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:71886
Deposited On:25 Apr 2022 07:41
Last Modified:25 Apr 2022 07:46

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