The Role of Immune Cells in Oxi-Inflamm-Aging

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Martínez de Toda Cabeza, Irene and Ceprián, Noemí and Díaz Del Cerro, Estefanía and Fuente del Rey, Mónica de la (2021) The Role of Immune Cells in Oxi-Inflamm-Aging. Cells, 10 (11). pp. 1-20. ISSN Electronic: 2073-4409

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Official URL: https://doi.org/10.3390/cells10112974




Abstract

Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.


Item Type:Article
Uncontrolled Keywords:Aging; Immune cells; Oxidative stress; Inflammatory stress; Biological age
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Animal physiology
ID Code:71983
Deposited On:29 Apr 2022 09:04
Last Modified:03 May 2022 06:39

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