Dalbavancin for the Treatment of Prosthetic Joint Infections: A Narrative Review



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Buzón Martín, Luis and Zollner Schwetz, Ines and Tobudic, Selma and Cercenado, Emilia and Lora Tamayo, Jaime (2021) Dalbavancin for the Treatment of Prosthetic Joint Infections: A Narrative Review. Antibiotics, 10 (6). p. 656. ISSN 2079-6382

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Official URL: https://doi.org/10.3390/antibiotics10060656


Dalbavancin (DAL) is a lipoglycopeptide with bactericidal activity against a very wide range of Gram-positive microorganisms. It also has unique pharmacokinetic properties, namely a prolonged half-life (around 181 h), which allows a convenient weekly dosing regimen, and good diffusion in bone tissue. These features have led to off-label use of dalbavancin in the setting of bone and joint infection, including prosthetic joint infections (PJI). In this narrative review, we go over the pharmacokinetic and pharmacodynamic characteristics of DAL, along with published in vitro and in vivo experimental models evaluating its activity against biofilm-embedded bacteria. We also examine published experience of osteoarticular infection with special attention to DAL and PJI.

Item Type:Article
Uncontrolled Keywords:dalbavancin; prosthetic joint infection; gram-positive
Subjects:Medical sciences > Medicine > Rheumatology
Medical sciences > Pharmacy
Medical sciences > Pharmacy > Pharmacology
ID Code:72087
Deposited On:17 May 2022 14:04
Last Modified:18 May 2022 08:33

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