Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)



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Estévez-Vázquez, Olga and Benedé-Ubieto, Raquel and Guo, Feifei and Gómez-Santos, Beatriz and Aspichueta, Patricia and Reissing, Johanna and Bruns, Tony and Sanz-García, Carlos and Sydor, Svenja and Bechmann, Lars P and Maranillo Alcaide, Eva and Sañudo Tejero, José Ramón and Vázquez Osorio, María Teresa and Lamas-Paz, Arantza and Morán, Laura and Mazariegos, Marina S and Ciudin, Andreea and Pericàs, Juan M. and Peligros, María Isabel and Vaquero, Javier and Martínez-Naves, Eduardo and Liedtke, Christian and Regueiro González-Barros, José Ramón and Trautwein, Christian and Bañares Cañizares, Rafael and Cubero Palero, Francisco Javier and Nevzorova, Yulia A. (2021) Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD). Biomedicines, 9 (10). pp. 1-17. ISSN Electronic 2227-9059

[thumbnail of Estévez-Vázquez, O. et al. 2021. Fat  Quality, or Quantity what matters.pdf]
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Official URL: https://doi.org/10.3390/biomedicines9101289


Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.

Item Type:Article
Uncontrolled Keywords:Obesity; Metabolic associated fatty liver disease (MAFLD); Steatohepatitis; Fibrosis; Palmitic acid (PA)
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Immunology
ID Code:72191
Deposited On:11 May 2022 11:24
Last Modified:12 May 2022 07:03

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