Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection



Downloads per month over past year

Barroso Arévalo, Sandra and Sánchez Morales, Lidia and Barasona García-Arévalo, José Ángel and Rivera Arroyo, Belén and Sánchez García, Rocío and Risalde, María A. and Agulló-Ros, Irene and Sánchez Vizcaíno, José Manuel (2022) Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection. Veterinary Research Communications . ISSN 0165-7380

[thumbnail of Barroso-Arévalo2022_Article_EvaluationOfTheClinicalEvoluti.pdf]
Creative Commons Attribution.


Official URL: https://doi.org/10.1007/s11259-022-09908-5


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic disease denominated as Coronavirus Disease 2019 (COVID-19). Several studies suggest that the original source of this virus was a spillover from an animal reservoir and its subsequent adaptation to humans. Of all the different animals affected, cats are one of the most susceptible species. Moreover, several cases of natural infection in domestic and stray cats have been reported in the last few months. Although experimental infection assays have demonstrated that cats are successfully infected and can transmit the virus to other cats by aerosol, the conditions used for these experiments have not been specified in terms of ventilation. We have, therefore, evaluated the susceptibility of cats using routes of infection similar to those expected under natural conditions (exposure to a sneeze, cough, or contaminated environment) by aerosol and oral infection. We have also evaluated the transmission capacity among infected and naïve cats using different air exchange levels. Despite being infected using natural routes and shed virus for a long period, the cats did not transmit the virus to contact cats when air renovation features were employed. The infected animals also developed gross and histological lesions in several organs. These outcomes confirm that cats are at risk of infection when exposed to infected people, but do not transmit the virus to other cats with high rates of air renovation.

Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:SARS-CoV-2, Cats, Transmission, Air renovation, Routes of infection
Subjects:Medical sciences > Veterinary > Pets
Medical sciences > Veterinary > Veterinary pathology
ID Code:72359
Deposited On:20 May 2022 13:22
Last Modified:23 May 2022 07:12

Origin of downloads

Repository Staff Only: item control page