Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis



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García Oreja, Sara and Álvaro Afonso, Francisco Javier and Tardáguila García, Aroa and López Moral, Mateo and García Madrid, Marta and Lázaro Martínez, José Luis (2022) Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis. Dermatologic Therapy . ISSN 1396-0296

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Official URL: https://doi.org/10.1111/dth.15480


Recent systematic reviews of plantar warts continue to consider cryotherapy as one of the treatments of choice, but this method appears to have lower cure rates than alternative treatments. A systematic review using meta-analyses of the efficacy of cryotherapy in plantar warts treatment was performed. Systematic electronic searches were conducted. The primary endpoint was complete clearance of plantar warts. Risk-of-bias assessment was based on Cochrane Handbook recommendations. Meta-analyses used Review Manager v5.4.1 software. Cryotherapy appears to have lower cure rates than other treatments (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.12–0.78) with substantial heterogeneity (I2 = 80%). A second subgroup analysis had low heterogeneity (I2 = 28.2%). Subgroup analysis showed that plantar wart cure rates were significantly lower with cryotherapy compared to the physical treatment group (OR 0.05, 95% CI 0.01–0.49) with substantial heterogeneity (I2 = 79%), and antiviral, chemotherapy, and retinoid group (OR 0.30, 95% CI 0.14–0.66) without heterogeneity (I2 = 0%). Intralesional versus spray-on cryotherapy appears to be more effective (OR 0.21, 95% CI 0.09–0.48). No difference in efficacy between two rounds of 10-s and four rounds of 5-s freeze–thaw cycles in cryotherapy was found. Evidence of the superiority of antivirals and chemotherapy over cryotherapy in the treatment of plantar warts was found. However, no evidence supports the superiority or inferiority of cryotherapy compared to other treatments.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:cryotherapy, HPV, human papillomavirus, meta-analyses, plantar warts, systematic review
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Nursing > Podiatry
ID Code:72368
Deposited On:19 May 2022 13:58
Last Modified:15 Jun 2022 09:52

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