Synthesis and impact of neuroestradiol on hippocampal neuronal networks



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Azcoitia Elías, Iñigo and Hernández Vivanco, Alicia and Cano Adamuz, Nuria and Méndez, Pablo (2022) Synthesis and impact of neuroestradiol on hippocampal neuronal networks. Current Opinion in Endocrine and Metabolic Research, 24 (100335). pp. 1-8. ISSN 2451-9650

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The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:Aromatase; Excitatory neurons; Estradiol; Estrogen; Hippocampus; Inhibitory neurons; Neurosteroids
Subjects:Medical sciences > Biology > Biochemistry
Medical sciences > Biology > Neurosciences
ID Code:72497
Deposited On:31 May 2022 11:10
Last Modified:13 Oct 2022 11:34

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