Publication: Regulación de la expresión de los receptores VPAC1 y VPAC2 en linfocitos T colaboradores humanos y su implicación funcional
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2022-06-02
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Universidad Complutense de Madrid
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Abstract
Debido al papel fundamental que juegan los linfocitos T CD4 en la coordinación de la respuesta inmune, la alteración y la perturbación de su actividad puede acarrear consecuencias como la aparición de procesos inflamatorios y autoinmunes. Las células T CD4 se encuentran en estrecha relación con los mediadores moleculares presentes en el microambiente, que pueden modular y alterar sus funciones y actividades. Entre esos mediadores encontramos a los neuropéptidos como VIP, el cual ha mostrado en numerosas ocasiones su potencial anti-inflamatorio u homeostático en condiciones patológicas, como la artritis reumatoide. Por ello, en la presente Tesis Doctoral, tratamos de desgranar, por un lado, la actividad del eje VIP/receptores sobre diferentes estados de activación o diferenciación de linfocitos T CD4 humanos y, por otro lado, la interacción de los receptores VPAC con los mediadores de sus rutas de señalización...
Due to their pivotal role monitoring and coordinating the immune response, alterations or disruptions in the CD4 T cell compartment could lead to the development of inflammatory or autoimmune diseases. CD4 lymphocytes are actively involved in the onset and development of the pathological state and are in close relationship with all the molecules from the microenvironment, which can modulate and disrupt their function. Neuropeptides, such as VIP, are found among those molecular mediators. It has been shown in several works its potential as anti-inflammatory or homeostatic mediator in pathological conditions, as rheumatoid arthritis (RA). Thus, the work related to this PhD thesis tries to analyse the role of VIP/receptors axis on different activation and differentiation states of human CD4 T cells, as well as the first steps in the downstream signalling of VPAC receptors...
Due to their pivotal role monitoring and coordinating the immune response, alterations or disruptions in the CD4 T cell compartment could lead to the development of inflammatory or autoimmune diseases. CD4 lymphocytes are actively involved in the onset and development of the pathological state and are in close relationship with all the molecules from the microenvironment, which can modulate and disrupt their function. Neuropeptides, such as VIP, are found among those molecular mediators. It has been shown in several works its potential as anti-inflammatory or homeostatic mediator in pathological conditions, as rheumatoid arthritis (RA). Thus, the work related to this PhD thesis tries to analyse the role of VIP/receptors axis on different activation and differentiation states of human CD4 T cells, as well as the first steps in the downstream signalling of VPAC receptors...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 21-03-2022