An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution

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Gil Etayo, Francisco Javier and Garcinuño, Sara and Utrero Rico, Alberto and Cabrera Marante, Oscar and Arroyo Sánchez, Daniel and Mancebo, Esther and Pleguezuelo, Daniel Enrique and Rodríguez Frías, Edgard and Allende Martínez, Luis Miguel and Morales Pérez, Pablo and Castro Panete, María José and Lalueza Blanco, Antonio and Lumbreras Bermejo, Carlos Juan and Paz Artal, Estela and Serrano, Antonio (2022) An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution. Biomedicines, 10 (2). p. 296. ISSN 2227-9059

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Official URL: https://doi.org/10.3390/biomedicines10020296




Abstract

The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is a determining factor in the evolution of infectious diseases. This work has aimed to evaluate the early, or on diagnosis, T-cell compartment response, T-helper subsets and anti-SARS-CoV-2 antibody specificity in COVID-19 patients and to classify them according to evolution based on infection severity. A unicenter, randomized group of 146 COVID-19 patients was divided into four groups in accordance with the most critical events during the course of disease. The immunophenotype and T-helper subsets were analyzed by flow cytometry. Asymptomatic SARS-CoV-2 infected individuals showed a potent and robust Th1 immunity, with a lower Th17 and less activated T-cells at the time of sample acquisition compared not only with symptomatic patients, but also with healthy controls. Conversely, severe COVID-19 patients presented with Th17-skewed immunity, fewer Th1 responses and more activated T-cells. The multivariate analysis of the immunological and inflammatory parameters, together with the comorbidities, showed that the Th1 response was an independent protective factor for the prevention of hospitalization (OR 0.17, 95% CI 0.03–0.81), with an AUC of 0.844. Likewise, the Th1 response was found to be an independent protective factor for severe forms of the disease (OR 0.09, 95% CI: 0.01–0.63, p = 0.015, AUC: 0.873). In conclusion, a predominant Th1 immune response in the acute phase of the SARS-CoV-2 infection could be used as a tool to identify patients who might have a good disease evolution.


Item Type:Article
Uncontrolled Keywords:COVID-19; Th1; T helper; cell mediated immunity; imbalanced immune response; Th17; Th2; T-cell subsets; SARS-CoV2
Subjects:Medical sciences > Medicine > Immunology
ID Code:72838
Deposited On:27 Jun 2022 14:51
Last Modified:28 Jun 2022 11:11

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