Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex

Impacto

Downloads

Downloads per month over past year

García Marchena, Nuria and Marcos, Alberto and Flores López, María and Moreno Fernández, Mario and Requena Ocaña, Nerea and Porras Perales, Oscar and Torres Galván, Sandra and Araos, Pedro and Serrano, Antonia and Muga, Roberto and Ruiz Ruiz, Juan Jesús and Rodríguez de Fonseca, Fernando and Ambrosio, Emilio and Pavón Morón, Francisco Javier (2022) Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex. Biomedicines, 10 (5). p. 1137. ISSN 2227-9059

[thumbnail of biomedicines-10-01137-v2.pdf]
Preview
PDF
Creative Commons Attribution.

1MB

Official URL: https://doi.org/10.3390/biomedicines10051137




Abstract

(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. (2) Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity (3) Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. (4) Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.


Item Type:Article
Uncontrolled Keywords:abstinence; alcohol use disorder; amino acids; biomarker; CE-LIF; cocaine use disorder; cross-sectional study; PRISM; psychiatric comorbidity; sex
Subjects:Medical sciences > Psychology > Drug abuse
ID Code:72844
Deposited On:17 Jun 2022 15:55
Last Modified:27 Jun 2022 08:35

Origin of downloads

Repository Staff Only: item control page